Ammonia → 2-Bromo-6-[4-(trifluoromethyl)phenyl]pyrazine

HRID 1269634노트

반응식

HRID 1269634 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.P(Br)(Br)[Br:19].N>O>[Br:19][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 24614Phosphorus tribromideHCID 184483272-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine

생성물 1

HCID 184483242-Bromo-6-[4-(trifluoromethyl)phenyl]pyrazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a flask containing 2-chloro-6-[4-(trifluoromethyl)phenyl]pyrazine (0.8 g, 3.1 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (400 mL), the resulting mixture was adjusted to pH 6–7 using aqueous ammonia and extracted with diethylether (3×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a pale yellow crystalline solid (0.97 g).

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 6 h under nitrogen
  3. extractionextracted with diethylether (3×250 mL)
  4. dry with materialThe organic solution was dried (MgSO4)
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-0ab5a336acef454597997fc74bea4031
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199239B2

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