Ammonia → 2-Bromo-6-(4-methylphenyl)pyrazine

HRID 1269635노트

반응식

HRID 1269635 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1.P(Br)(Br)[Br:16].N>O>[Br:16][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 24614Phosphorus tribromideHCID 184483262-Chloro-6-(4-methylphenyl)pyrazine

생성물 1

HCID 184483232-Bromo-6-(4-methylphenyl)pyrazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a flask containing 2-chloro-6-(4-methylphenyl)pyrazine (2.5 g, 12.3 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (600 mL). The resulting solution was adjusted to pH 6–7 using aqueous ammonia and extracted with Et2O (2×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a white solid (2.32 g).

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 6 h under nitrogen
  3. extractionextracted with Et2O (2×250 mL)
  4. dry with materialThe organic solution was dried (MgSO4)
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-27f4149e1e044c8ebf87231a73f422a9
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199239B2

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