홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → Ethyl {4-[((2-methoxyethyl){6-[4-(trifluoromethyl) phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

HRID 1269638
노트
인쇄 미리보기

반응식

HRID 1269638 반응식
Br[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.C(N(CC)C(C)C)(C)C.[CH3:27][O:28][CH2:29][CH2:30][NH:31][CH2:32][C:33]1[CH:45]=[CH:44][C:36]([O:37][CH2:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:35]([CH3:46])[CH:34]=1>O>[CH3:27][O:28][CH2:29][CH2:30][N:31]([CH2:32][C:33]1[CH:45]=[CH:44][C:36]([O:37][CH2:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:35]([CH3:46])[CH:34]=1)[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 184483242-Bromo-6-[4-(trifluoromethyl)phenyl]pyrazineHCID 58622873Ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate

생성물 1

HCID 58622890Ethyl {4-[((2-methoxyethyl){6-[4-(trifluoromethyl) phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate수율 19.3%

시약·촉매·용매 1

HCID 962
Water
용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-bromo-6-[4-(trifluoromethyl)phenyl]pyrazine (0.5 g, 1.65 mmol), N,N-diisopropylethylamine (0.29 mL, 1.65 mmol) and ethyl (4-{[(2-methoxyethyl)amino]methyl}-2-methylphenoxy)acetate (0.7 g, 2.47 mmol) was heated at 100° C. in a sealed reactivial for 20 h. The reaction mixture was then allowed to come to room temperature, and the residue was diluted with water (40 mL) and extracted CH2Cl2 (2×40 mL). The organic extract was passed through a hydrophobic frit and concentrated in vacuo. Purification by Biotage™ chromatography (Silica, 90 g) eluting 1:19–1:4 EtOAc:cyclohexane afforded the title compound as a pale yellow oil (0.16 g).

후처리

  1. customto come to room temperature
  2. extractionextracted CH2Cl2 (2×40 mL)
  3. extractionThe organic extract
  4. concentrationconcentrated in vacuo
  5. customPurification by Biotage™ chromatography (Silica, 90 g)
  6. washeluting 1:19–1:4 EtOAc

출처 및 근거

ORD 기록
ord-618aea29db5148b982dbdabc333387f2
출처 데이터셋
uspto-grants-2007_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07199239B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트