Acetic Anhydride → N-(4-cyano-2,3-dimethylphenyl)acetamide

HRID 1269863노트

반응식

HRID 1269863 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([CH3:17])[C:10]=1[CH3:18]>C(OCC)(=O)C>[C:13]([C:12]1[CH:15]=[CH:16][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[C:10]([CH3:18])[C:11]=1[CH3:17])#[N:14]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 199903354-Amino-2,3-dimethylbenzonitrile

생성물 1

HCID 22934081N-(4-cyano-2,3-dimethylphenyl)acetamide수율 81.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Acetic anhydride (1.36 ml, 14.4 mmol) was added to a solution of 4-amino-2,3-dimethylbenzonitrile (1.32 g, 9.03 mmol) in ethyl acetate (10 ml) at room temperature, and then the reaction was carried out for 4 hours under reflux conditions. After the reaction mixture was cooled, the precipitate obtained was collected by filtration and dried to obtain N-(4-cyano-2,3-dimethylphenyl)acetamide (1.39 g, 81.8%).

후처리

  1. temperatureAfter the reaction mixture was cooled
  2. customthe precipitate obtained
  3. filtrationwas collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-a84cea353cc84605af45e385dc594a57
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199147B2

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