N-bromobutanimide → 1H-Indazol-5-ol,4-broMo-

HRID 1269919노트

반응식

HRID 1269919 반응식
[Br:1]N1C(=O)CCC1=O.[NH:9]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[CH:11]=[N:10]1>O1CCCC1>[Br:1][C:13]1[C:14]([OH:18])=[CH:15][CH:16]=[C:17]2[C:12]=1[CH:11]=[N:10][NH:9]2

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 1014381H-Indazol-5-ol

생성물 1

HCID 229341081H-Indazol-5-ol,4-broMo-수율 91%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-bromosuccinimide (1.06 g, 5.96 mmol) was added to a solution of the 1H-indazol-5-ol (800 mg, 5.96 mmol) obtained in Reference Example 4 in tetrahydrofuran (20 ml) at room temperature. The resulting mixture was stirred for 14 hours while being maintained at room temperature. The mixture was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate) to obtain 4-bromo-1H-indazol-5-ol (1.15 g, 91%).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-71418cc7433644339b4d46e5fc3fbccc
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199147B2

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