Hydrogen Bromide → 4-(2-Oxo-1-cyclopentylidenemethyl)phenylacetic acid
반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][C:3]1=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1.Br>O1CCOCC1>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][C:3]1=[CH:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1참가 물질
4
실험 절차
A mixture of 0.4 g of ethyl 4-(2-oxo-1-cyclopentylidenemethyl)phenylacetate in 100 ml of a 10% aqueous solution of hydrobromic acid and 10 ml of dioxane was heated under reflux for 1 hour. After cooling, the reaction mixture was extracted with ether, an ether layer was washed with water and dried. The ether was distilled off and the residual oily substance was distilled under reduced pressure to give 0.1 g of an oily substance having a boiling point of 205°-210° C./0.25 mmHg.
후처리
- temperaturewas heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling
- extractionthe reaction mixture was extracted with ether
- washan ether layer was washed with water
- customdried
- distillationThe ether was distilled off
- distillationthe residual oily substance was distilled under reduced pressure
- customto give 0.1 g of an oily substance
출처 및 근거
- ORD 기록
- ord-f473556008f04e2dbf8d458f532c78a2
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04254274
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