Ethylenediamine → N-pyridin-3-ylethane-1,2-diamine
반응식
[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.CC(C)([O-])C.[K+]>O>[N:8]1[CH:9]=[CH:10][CH:11]=[C:6]([NH:3][CH2:2][CH2:1][NH2:4])[CH:7]=1참가 물질
5
반응 조건
- 온도
- 118 °C
실험 절차
A mixture of 1.32 g of ethylenediamine, 250 mg of 3-chloropyridine, and 740 mg of potassium tert-butoxide was heated at 118° C. in a sealed tube for 18 hrs. The reaction was cooled to room temperature, diluted with water and extracted with chloroform. The organic extracts were dried over sodium sulfate, filtered, and concentrated to give the title product as a red oil. MS (M+H)+=137.9.
후처리
- temperatureThe reaction was cooled to room temperature
- extractionextracted with chloroform
- dry with materialThe organic extracts were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e1de8f5f0dc94312969d7dcbc46c29b9
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07202245B2
반응 노트
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