Diethyl Oxalate → Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate

반응식

[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1.C([O:15][C:16](=O)[C:17](OCC)=[O:18])C>>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[C:6]2[C:7](=[CH:8][CH:9]=1)[NH:10][C:16](=[O:15])[C:17](=[O:18])[NH:11]2)=[O:12]

참가 물질

반응물 2

HCID 7268Diethyl Oxalate

HCID 1355243,5-Diamino-2-methylbenzoic acid

생성물 1

HCID 23847563Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate

반응 조건

온도: 23 °C

실험 절차

A mixture of methyl-3,4-diaminobenzoate (4.5 g) in diethyloxalate (50 mL) was heated at reflux for three hrs. After cooling to 23° C., the solid was isolated by filtration, affording 2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid methyl ester as a light yellow solid. MS (M−H)−=219.1.

후처리

temperaturewas heated
temperatureat reflux for three hrs
customthe solid was isolated by filtration

출처 및 근거

ORD 기록: ord-cec1be3dd0604c3991de92514d48098e
출처 데이터셋: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07202245B2

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