Hydrazine hydrate (1:1) → 8-(2-Acetaminobenzyl)-3-[2-(4-aminophenyl)ethyl]-1-propylxanthine

HRID 1270226노트

반응식

HRID 1270226 반응식
[NH:1]([C:5]1[CH:36]=[CH:35][CH:34]=[CH:33][C:6]=1[CH2:7][C:8]1[NH:16][C:15]2[C:14](=[O:17])[N:13]([CH2:18][CH2:19][CH3:20])[C:12](=[O:21])[N:11]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=3)[C:10]=2[N:9]=1)[C:2]([CH3:4])=[O:3].O.NN.[H][H]>[Pd]>[NH:1]([C:5]1[CH:36]=[CH:35][CH:34]=[CH:33][C:6]=1[CH2:7][C:8]1[NH:16][C:15]2[C:14](=[O:17])[N:13]([CH2:18][CH2:19][CH3:20])[C:12](=[O:21])[N:11]([CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][C:27]([NH2:30])=[CH:28][CH:29]=3)[C:10]=2[N:9]=1)[C:2]([CH3:4])=[O:3]

참가 물질

5

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 184495338-(2-Acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 117539978-(2-Acetaminobenzyl)-3-[2-(4-aminophenyl)ethyl]-1-propylxanthine

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

By the method of Example 2, 2-(acetamino)phenylacetic acid is reacted with 5,6-diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil (6) to yield 8-(2-acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine. By methods well known in the art, 8-(2-acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine is reduced with hydrazine hydrate or hydrogen gas in the presence of a palladium catalyst to yield 8-(2-acetaminobenzyl)-3-[2-(4-aminophenyl)ethyl]-1-propylxanthine.

출처 및 근거

ORD 기록
ord-1b446be89d3c42768450544c0526c2f4
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202252B2

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