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[CH3:1][C@H:2]1[C@@:41]2([OH:43])[O:42][C@H:5]([CH2:6][C@H:7]([O:64][CH3:65])[C:8]([CH3:63])=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][C@@H:14]([CH3:62])[CH2:15][C@@H:16]([CH3:61])[C:17]([C@H:19]([O:59][CH3:60])[C@H:20]([OH:58])[C:21]([CH3:57])=[CH:22][C@@H:23]([CH3:56])[C:24]([CH2:26][C@@H:27]([C@@H:44]([CH2:46][C@H:47]3[CH2:52][C@@H:51]([O:53][CH3:54])[C@H:50]([OH:55])[CH2:49][CH2:48]3)[CH3:45])[O:28][C:29]([C@H:31]3[N:36]([C:37]([C:39]2=[O:40])=[O:38])[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:30])=[O:25])=[O:18])[CH2:4][CH2:3]1.[OH:66][CH2:67][C:68]([CH2:73][OH:74])([CH3:72])[C:69](O)=[O:70]>>[CH3:1][C@H:2]1[C@@:41]2([OH:43])[O:42][C@H:5]([CH2:6][C@H:7]([O:64][CH3:65])[C:8]([CH3:63])=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][C@@H:14]([CH3:62])[CH2:15][C@@H:16]([CH3:61])[C:17]([C@H:19]([O:59][CH3:60])[C@H:20]([OH:58])[C:21]([CH3:57])=[CH:22][C@@H:23]([CH3:56])[C:24]([CH2:26][C@@H:27]([C@@H:44]([CH2:46][C@H:47]3[CH2:52][C@@H:51]([O:53][CH3:54])[C@H:50]([O:55][C:67]([C:68]([CH2:73][OH:74])([CH2:69][OH:70])[CH3:72])=[O:66])[CH2:49][CH2:48]3)[CH3:45])[O:28][C:29]([C@H:31]3[N:36]([C:37]([C:39]2=[O:40])=[O:38])[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:30])=[O:25])=[O:18])[CH2:4][CH2:3]1참가 물질
3
실험 절차
The synthesis requires two steps. The first step is a microbial lipase-catalyzed acylation of rapamycin with an activated ester of 2,2-bis(hydroxymethyl)propionic acid derivative in an organic solvent. This reaction is highly regioselective, resulting in the exclusive formation of mono-42-acylated product (i.e., protected CCI-779), in nearly quantitative yield. Subsequent deprotection furnishes CCI-779 in excellent overall yield. Compared with chemical preparation, this chemo-enzymatic route offers a much shorter procedure with higher yield. Further, this method does not require any steps to protect the rapamycin's 31-OH group.
출처 및 근거
- ORD 기록
- ord-f2592ea2ac0d4fe0800757611b434f23
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07202256B2
연결된 노트
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