Phenylurea → 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione

HRID 1270557

반응식

HRID 1270557 반응식
[C:1]1([NH:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:12]([S:14]Cl)=[O:13]>C1COCC1>[C:1]1([N:7]2[C:8](=[O:9])[NH:10][C:12](=[O:13])[S:14]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 6145PhenylureaHCID 75990(Chlorothio)formyl chloride

생성물 1

HCID 184498842-Phenyl-1,2,4-thiadiazolidine-3,5-dione수율 20%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To the solution of phenyl-urea (13.0 g, 95.48 mol) in THF (100 mL) was slowly added chlorocarbonyl sulfenylchloride (13 mL, 148.85 mmol) at RT. The reaction mixture was refluxed overnight, the volatiles removed in vacuo yielded 2-phenyl-1,2,4-thiadiazolidine-3,5-dione as a white solid (4.0 g, 20%). 1H NMR (DMSO-d6): δ 12.49 (s, 1H), 7.51 (d, J=8.0 Hz, 2H), 7.43 )t, J=7.6 Hz, 2H), 7.27 (t, J=7.2 Hz, 1H).

후처리

  1. customat RT
  2. temperatureThe reaction mixture was refluxed overnight
  3. customthe volatiles removed in vacuo

출처 및 근거

ORD 기록
ord-64e0cb0f60d3469799b062732197bd1b
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202257B2

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