N-bromobutanimide → 4-Bromo-3,5-difluoroaniline

HRID 1270728

반응식

HRID 1270728 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].C1C(=O)N([Br:17])C(=O)C1>CN(C=O)C.CCOCC>[Br:17][C:8]1[C:2]([F:1])=[CH:3][C:4]([NH2:5])=[CH:6][C:7]=1[F:9]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 965953,5-Difluoroaniline

생성물 1

HCID 27362604-Bromo-3,5-difluoroaniline

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

3,5-Difluoroaniline (10.0 g, 77.5 mmol) is dissolved in DMF (100 mL). NBS (13.9 g, 78.0 mmol) is added portionwise at room temperature. After stirring overnight at room temperature, the reaction mixture is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil which is purified by column chromatography (methylene chloride/hexanes) to give 4-bromo-3,5-difluoroaniline.

후처리

  1. washwashed with brine
  2. dry with materialThe separated organic phase is dried (Na2SO4)
  3. concentrationconcentrated
  4. customto give an oil which
  5. customis purified by column chromatography (methylene chloride/hexanes)

출처 및 근거

ORD 기록
ord-e552a0d6f13146c99cc37f51be6c777b
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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