Chlorosuccinimide → 4-Bromo-2-chloro-3,5-difluoroaniline

HRID 1270729

반응식

HRID 1270729 반응식
[Br:1][C:2]1[C:8]([F:9])=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:10].C1C(=O)N([Cl:18])C(=O)C1>CN(C=O)C.CCOCC>[Br:1][C:2]1[C:8]([F:9])=[CH:7][C:5]([NH2:6])=[C:4]([Cl:18])[C:3]=1[F:10]

참가 물질

5

반응물 2

HCID 31398ChlorosuccinimideHCID 27362604-Bromo-3,5-difluoroaniline

생성물 1

HCID 184515214-Bromo-2-chloro-3,5-difluoroaniline

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

4-Bromo-3,5-difluoroaniline (10.5 g, 50.5 mmol) is dissolved in DMF (100 mL). NCS (28.6 g, 50.5 mmol) is added portionwise at room temperature. After 48 hours, the reaction is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil. The residue is purified by column chromatography (EtOAc/hexanes) to give 4-bromo-2-chloro-3,5-difluoroaniline.

후처리

  1. washwashed with brine
  2. dry with materialThe separated organic phase is dried (Na2SO4)
  3. concentrationconcentrated
  4. customto give an oil
  5. customThe residue is purified by column chromatography (EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-412f43e343fe4ce2a34aeef9f39f29dd
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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