Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorosuccinimide → 4-Bromo-2-chloro-3,5-difluoroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | 4-Bromo-3,5-difluoroaniline | HCID 2736260 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Bromo-2-chloro-3,5-difluoroaniline | HCID 18451521 | — |
반응 단계
4-Bromo-3,5-difluoroaniline (10.5 g, 50.5 mmol) is dissolved in DMF (100 mL). NCS (28.6 g, 50.5 mmol) is added portionwise at room temperature. After 48 hours, the reaction is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil. The residue is purified by column chromatography (EtOAc/hexanes) to give 4-bromo-2-chloro-3,5-difluoroaniline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07202364B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-412f43e343fe4ce2a34aeef9f39f29dd |
| 출처 메모 | uspto-grants-2007_04 |