Water → 6-Fluoro-2-naphthoic acid

HRID 1270766

반응식

HRID 1270766 반응식
C([O:3][C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:16])[CH:12]=2)[CH:7]=1)=[O:5])C.[OH-].[Na+].O>C(O)C>[F:16][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:15]=[CH:14]2

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68806046Ethyl 6-fluoro-2-naphthoate

생성물 1

HCID 27827886-Fluoro-2-naphthoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 6-fluoro-2-naphthoic acid ethyl ester (600 mg, 2.75 mmol) in ethanol (10 mL) at room temperature, is added 1 N NaOH (2.75 mL, 2.75 mmol). After stirring at room temperature for 4 hours, water (10 mL) is added. Acidification (2 N HCl) and filtration gives 6-fluoro-2-naphthoic acid as a white solid.

후처리

  1. filtrationAcidification (2 N HCl) and filtration

출처 및 근거

ORD 기록
ord-beb3c2a74c504d8183c0a7a6eab40b50
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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