Sodium Hydroxide → Tert-butyl 4-(trifluoromethoxy)phenylcarbamate

HRID 1270788노트

반응식

HRID 1270788 반응식
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.[C:13](=O)([O:19]C(C)(C)C)[O:14][C:15]([CH3:18])([CH3:17])[CH3:16].[OH-].[Na+]>C1COCC1>[C:13]([NH:8][C:7]1[CH:9]=[CH:10][C:4]([O:3][C:2]([F:11])([F:12])[F:1])=[CH:5][CH:6]=1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:19]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 6008484-(Trifluoromethoxy)anilineHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

생성물 1

HCID 11196668Tert-butyl 4-(trifluoromethoxy)phenylcarbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Trifluoromethoxyaniline (100 g, 0.58 mol), di-tert-butyl carbonate (127 g, 0.58 mol) and 1 N NaOH solution (250 mL) are dissolved in THF (200 mL) and stirred at room temperature for 12 hours. The reaction mixture is extracted with EtOAc (500 mL). The organic layer is washed with 1 N HCl (500 mL), brine (250 mL) and dried (MgSO4). The solvent is removed by rotary evaporator to give N-BOC-4-trifluoromethoxyaniline.

후처리

  1. extractionThe reaction mixture is extracted with EtOAc (500 mL)
  2. washThe organic layer is washed with 1 N HCl (500 mL), brine (250 mL)
  3. dry with materialdried (MgSO4)
  4. customThe solvent is removed by rotary evaporator

출처 및 근거

ORD 기록
ord-5b342cadb8244c19a82371722e2f902c
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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