N-bromobutanimide → N-(4-bromo-2-(bromomethyl)phenyl)-2,2,2-trifluoroacetamide
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([CH3:15])[CH:3]=1.[Br:16]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[C:10]([F:12])([F:13])[F:11])=[C:4]([CH2:15][Br:16])[CH:3]=1참가 물질
4
실험 절차
A solution of Example 478A (2.5 g, 8.9 mmol) and N-bromosuccinimide (1.58 g, 8.9 mmol) in carbon tetrachloride (25 mL) was irradiated with a 100-watt incandescent bulb overnight. The solution was filtered and the filtrate was concentrated. The concentrate was purified by flash chromatography on silica gel using 3–4% ethyl acetate/hexanes to give 2.17 g (68% yield) of the desired product. MS (ESI(−)) m/e 360, 362 (M−H)−.
후처리
- filtrationThe solution was filtered
- concentrationthe filtrate was concentrated
- customThe concentrate was purified by flash chromatography on silica gel using 3–4% ethyl acetate/hexanes
출처 및 근거
- ORD 기록
- ord-885075b6c9d749509f2df4408bb04a61
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07202363B2
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