Acetaldehyde → HCID 18452869, 화합물

HRID 1271220노트

반응식

HRID 1271220 반응식
N[C:2]1C=NC=N[CH:7]=1.C(=O)C.[H][H].[CH2:13]([NH:15][C:16]1[CH:17]=[N:18][CH:19]=[N:20][CH:21]=1)[CH3:14]>C(O)C.O=[Pt]=O>[CH2:13]([N:15]([C:16]1[CH:17]=[N:18][CH:19]=[N:20][CH:21]=1)[CH2:2][CH3:7])[CH3:14]

참가 물질

7

반응물 4

HCID 177AcetaldehydeHCID 344373Pyrimidin-5-amineHCID 694722071368022-07-4HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 18452869HCID 18452869, 화합물

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A suspension of the 5-aminopyrimidine, and one twenty-fifth an equal mass of PtO2, and 5 equivalents equivalents of aqueous acetaldehyde, in ethanol solvent, was shaken under 60 psi hydrogen gas for 24 h. At this time, TLC of an evaporated aliquot of the reaction mixture indicated complete conversion of the 5-(N-ethyl)aminopyrimidine. The Pt catalyst was removed by filtering the reaction mixture through Celite, and the 5-(N,N-diethyl)aminopyrimidine was isolated by evaporation of the ethanol solvent. The crude product was purified by flash chromatography on silica using EtOAc/hexanes.

후처리

  1. customThe Pt catalyst was removed
  2. filtrationby filtering the reaction mixture through Celite

출처 및 근거

ORD 기록
ord-d24865bc7b22419b8a1bf849372426e2
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205310B2

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