Ethanol → 1-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

HRID 1271243노트

반응식

HRID 1271243 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([OH:20])C>C(OCC)=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH:17][CH:18]=[O:20])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 702EthanolHCID 2074152-(3-(Benzyloxy)phenyl)ethanamine

생성물 1

HCID 229319731-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

시약·촉매·용매 1

HCID 8025Ethyl formate용매

실험 절차

To a solution of 8.60 g of 2-[3-(benzyloxy)phenyl]ethylamine in 50 ml of ethanol, 4.6 ml of ethyl formate was added and the mixture was heated at reflux for 18 hours. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to obtain 4.81 g of the desired compound as a pale orange oily substance.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-8939681e3cad4e74a0f12206f384ff5a
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205302B2

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