Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1271301생성일: 2026년 10월 27일
2-(4-Pentynyloxy)tetrahydro-2H-pyran → 5,6-Diphenyl-2-[5-(2-tetrahydropyranyloxy)-1-pentyn-1-yl]pyrazine
https://huagongshe.com/reaction/1271301
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(4-Pentynyloxy)tetrahydro-2H-pyran | HCID 357816 | — |
| 반응물 | 5-Chloro-2,3-Diphenylpyrazine | HCID 3654493 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 5,6-Diphenyl-2-[5-(2-tetrahydropyranyloxy)-1-pentyn-1-yl]pyrazine | HCID 22931955 | 75.8% |
반응 단계
To a solution of 1.58 g of 2-chloro-5,6-diphenylpyrazine in 10 ml of triethylamine, 1.20 g of 5-(2-tetrahydropyranyloxy)-1-pentyne, 208 mg of dichlorobis(triphenylphosphine)palladium (II) and 56 mg of copper (I) iodide were added, followed by stirring under an argon atmosphere at 80° C. for 8 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in diethyl ether, and then the insoluble matter was removed by filtration through celite. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to obtain 1.79 g of the desired compound as a brown oily substance.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07205302B2 |
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| 출처 데이터셋 | uspto-grants-2007_04 |
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| ORD ID | ord-30c9cb5a484e4641a505c92c2d64f0e7 |
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| 출처 메모 | uspto-grants-2007_04 |
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