2-Methylbenzenesulfonic acid → 2-Bromomethyl-4-methyl-1,3-dioxane

반응식

[Br:1][CH2:2][CH:3](OC)OC.[CH2:8]([OH:13])[CH2:9][CH:10]([OH:12])[CH3:11].C1(C)C(S(O)(=O)=O)=CC=CC=1>>[Br:1][CH2:2][CH:3]1[O:12][CH:10]([CH3:11])[CH2:9][CH2:8][O:13]1

참가 물질

반응물 3

HCID 69252-Methylbenzenesulfonic acid

HCID 78961,3-Butanediol

HCID 816722-Bromo-1,1-dimethoxyethane

생성물 1

HCID 99902352-Bromomethyl-4-methyl-1,3-dioxane

실험 절차

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.