2-Methylbenzenesulfonic acid → 2-Bromomethyl-4-methyl-1,3-dioxane

HRID 127133

반응식

HRID 127133 반응식
[Br:1][CH2:2][CH:3](OC)OC.[CH2:8]([OH:13])[CH2:9][CH:10]([OH:12])[CH3:11].C1(C)C(S(O)(=O)=O)=CC=CC=1>>[Br:1][CH2:2][CH:3]1[O:12][CH:10]([CH3:11])[CH2:9][CH2:8][O:13]1

참가 물질

4

반응물 3

HCID 69252-Methylbenzenesulfonic acidHCID 78961,3-ButanediolHCID 816722-Bromo-1,1-dimethoxyethane

생성물 1

HCID 99902352-Bromomethyl-4-methyl-1,3-dioxane

실험 절차

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

후처리

  1. customfitted with a mechanical stirrer
  2. temperaturethermometer, Dean Stark trap and reflux condenser
  3. temperaturethe reaction mixture is heated
  4. customalcohol removed
  5. additiontreated with sodium carbonate (5 grams)
  6. filtrationfiltered
  7. customa rotary evaporator

출처 및 근거

ORD 기록
ord-1ad4f162cba04b13afc719abe876680b
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255182

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