2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone

HRID 1271682

반응식

HRID 1271682 반응식
[C:1](C1NC=CN=1)(C1NC=CN=1)=[O:2].[NH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[OH:21]>ClCCl>[F:20][C:18]1[CH:17]=[CH:16][C:15]2[O:21][C:1](=[O:2])[NH:13][C:14]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 27359172-Amino-4-fluorophenolHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

생성물 1

HCID 2872085-Fluoro-2(3H)-benzoxazolone수율 67%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).

후처리

  1. washAfter 14 hours the solution was washed with 5M aqueous HCl, water
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe solution was filtered through a plug of silica
  4. customevaporated

출처 및 근거

ORD 기록
ord-4546198c3ac949d9ac091528485bf21a
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205408B2

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