Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-4-fluorophenol | HCID 2735917 | — |
| 반응물 | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Fluoro-2(3H)-benzoxazolone | HCID 287208 | 67% |
반응 단계
Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07205408B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-4546198c3ac949d9ac091528485bf21a |
| 출처 메모 | uspto-grants-2007_04 |