2-Bromoethanol → 2-(2-Iodo-6-methylpyridin-3-yloxy)ethanol

HRID 1271687노트

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HRID 1271687 반응식
[I:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.Br[CH2:11][CH2:12][OH:13]>[OH-].[Na+]>[I:1][C:2]1[C:7]([O:8][CH2:11][CH2:12][OH:13])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1

참가 물질

4

반응물 2

HCID 108982-BromoethanolHCID 899572-Iodo-6-methylpyridin-3-ol

생성물 1

HCID 218737982-(2-Iodo-6-methylpyridin-3-yloxy)ethanol

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

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온도
100 °C

실험 절차

2-Iodo-6-methyl-pyridin-3-ol (6.49 g, 27.6 mmol) was stirred in a 1M solution of sodium hydroxide (30 ml). To this was added 1-bromoethan-2-ol (3.91 ml, 55.20 mmol) dropwise at room temperature. The resulting solution was then heated to 100° C. and stirred for 2 hours. The reaction mixture was cooled and then extracted into chloroform (2×100 ml). The organic phases were combined and extracted with a solution of 1M sodium hydroxide (25 ml). The organic phase was then dried over magnesium sulfate and concentrated in vacuo. This provided the desired product which was used without further purification (5.26 g).

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted into chloroform (2×100 ml)
  3. extractionextracted with a solution of 1M sodium hydroxide (25 ml)
  4. dry with materialThe organic phase was then dried over magnesium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-55d71aeb95da414f97dd5dd9a07b5e13
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205408B2

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