Bromine → Methyl 6-amino-3,5-dibromopicolinate

HRID 1271698노트

반응식

HRID 1271698 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([Br:12])=[CH:4][CH:3]=1.[Br:13]Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([Br:12])=[CH:4][C:3]=1[Br:13]

참가 물질

4

반응물 2

HCID 24408BromineHCID 10657127Methyl 6-amino-3-bromopyridine-2-carboxylate

생성물 1

HCID 10495131Methyl 6-amino-3,5-dibromopicolinate

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of methyl 6-amino-3-bromopyridine-2-carboxylate (20.62 g) (T. R. Kelly and F. Lang, J. Org. Chem. 61, 1996, 4623–4633) in chloroform (570 ml) was treated dropwise over 2 hours with bromine (4.62 ml) in chloroform (115 ml) and stirred 16 hours. The solution was washed with excess aqueous sodium bicarbonate, dried and evaporated. Crystallisation from EtOAc/hexane gave a solid (13.5 g).

후처리

  1. washThe solution was washed with excess aqueous sodium bicarbonate
  2. customdried
  3. customevaporated
  4. customCrystallisation from EtOAc/hexane

출처 및 근거

ORD 기록
ord-969f8afdac3340dfa25a62aa19e8cfc9
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205408B2

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