6-Methoxypyridine-3-carbaldehyde → Ethyl 3-(6-methoxy-3-pyridyl)acrylate
반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=O)=[CH:5][CH:4]=1.[C:11]([O:17][CH2:18][CH3:19])(=[O:16])[CH2:12]C([O-])=O>N1CCCCC1.N1C=CC=CC=1>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[CH:12][C:11]([O:17][CH2:18][CH3:19])=[O:16])=[CH:5][CH:4]=1참가 물질
5
실험 절차
A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%), m.p. 49-52°.
후처리
- temperaturewas heated
- temperatureunder reflux for 5 hours
- customwas evaporated to an oil
- customThis oil was partitioned between ether and dilute aqueous ammonia
- washThe ether layer was washed with water
- customevaporated to an oil which
- customcrystallised
출처 및 근거
- ORD 기록
- ord-0e168bd7f1a34e58b18e711c954c5def
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04255428
반응 노트
불러오는 중…