Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| 반응물 | 2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 12783832 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 12788664 | 63% |
반응 단계
An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(5-methyl-4-imidazolyl methylthio)-ethylamine was refluxed in ethanol for 18 hours. The solid which crystallised out on cooling was recrystallised from ethanol to give 2-[2-(5-methyl-4-imidazolyl methylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone, m.p. 197-198.5° in 63% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255428 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-1c7e88ed812345bc8e7159816fe82d56 |
| 출처 메모 | uspto-grants-1981_03 |