Methanol → 2-Methoxyisonicotinonitrile

HRID 127201

반응식

HRID 127201 반응식
[Na].Cl[C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1.[CH3:11][OH:12]>>[CH3:11][O:12][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 5686382-Chloro-4-cyanopyridineHCID 5360545Sodium

생성물 1

HCID 72048872-Methoxyisonicotinonitrile수율 51%

실험 절차

Sodium (20.8 g) was dissolved in methanol (285 ml), a solution of 2-chloro-4-cyanopyridine (115.53 g) in methanoldioxan (1:1, 850 ml) was added and the mixture was boiled under reflux for 21/2 hours and was allowed to cool. The mixture was filtered and the volume of the filtrate was reduced by evaporation in 200 ml and water (400 ml) was added. The solid which precipitated out was filtered off to give 2-methoxy-4-cyanopyridine (57.2 g, 51%), m.p. 93-95.5°.

후처리

  1. temperatureunder reflux for 21/2 hours
  2. temperatureto cool
  3. filtrationThe mixture was filtered
  4. customthe volume of the filtrate was reduced by evaporation in 200 ml and water (400 ml)
  5. additionwas added
  6. customThe solid which precipitated out
  7. filtrationwas filtered off

출처 및 근거

ORD 기록
ord-c53e5f015c9a439dbf227b810b1f574a
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255428

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