Hydroxyamine hydrochloride → 4-Fluoro-2-(5-isoxazolyl)phenol
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]=[CH:6][C:5]2=[O:12].Cl.[NH2:14]O>C(O)C>[F:1][C:2]1[CH:11]=[CH:10][C:9]([OH:8])=[C:4]([C:5]2[O:12][N:14]=[CH:7][CH:6]=2)[CH:3]=1참가 물질
4
실험 절차
The product from above (6-fluorochromen-4-one (5.25 g, 32.0 mmol) and hydroxylamine hydrochloride (4.65 g, 67.2 mmol) are dissolved in ethanol (180 ml) and the resulting mixture is heated to reflux. The reaction is allowed to stir for 18 hours before cooling and concentrating. The residue is taken up in toluene and filtered to give 690 mg of 4-fluoro-2-isoxazol-5-yl-phenol and from the filtrate 594 mg of 4-fluoro-2-isoxazol-3-yl-phenol.
후처리
- temperaturethe resulting mixture is heated to reflux
- temperaturebefore cooling
- concentrationconcentrating
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-4ac770502896430e878b8a40f36d127a
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07208505B2
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