Hydrochloric Acid → 5-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride
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[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1참가 물질
4
실험 절차
5-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep98, 350 mg, 1.4 mmol) was dissolved in a solution of 4N HCl in dioxane solution (5 ml). After refluxing the solution for 30 minutes, the solvent was removed under vacuum to give 300 mg of the title compound as a white powder (83% yield).
후처리
- temperatureAfter refluxing the solution for 30 minutes
- customthe solvent was removed under vacuum
출처 및 근거
- ORD 기록
- ord-d3ebb2c1593c4fd898af205b82c80f21
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07727988B2
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