Hydrochloric Acid → 5-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12723

반응식

HRID 12723 반응식
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 589941695-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine

생성물 1

HCID 686920285-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride수율 83%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep98, 350 mg, 1.4 mmol) was dissolved in a solution of 4N HCl in dioxane solution (5 ml). After refluxing the solution for 30 minutes, the solvent was removed under vacuum to give 300 mg of the title compound as a white powder (83% yield).

후처리

  1. temperatureAfter refluxing the solution for 30 minutes
  2. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-d3ebb2c1593c4fd898af205b82c80f21
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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