3-Aminopyridine → 8-(3-Pyridyl)-8-azaspiro[4,5]decan-7,9-dione
반응식
[CH2:1]1[CH2:5][C:4]2([CH2:12][C:10](=[O:11])[O:9][C:7](=O)[CH2:6]2)[CH2:3][CH2:2]1.[NH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1>C1(C)C(C)=CC=CC=1>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:13]2[C:7](=[O:9])[CH2:6][C:4]3([CH2:3][CH2:2][CH2:1][CH2:5]3)[CH2:12][C:10]2=[O:11])[CH:15]=1참가 물질
4
실험 절차
The starting material is prepared as follows. The mixture of 16.8 g of 3,3-tetramethyleneglutaric anhydride, 9.4 g of 3-aminopyridine and 225 ml of xylene is stirred and refluxed for 48 hours while collecting the water formed. After cooling in the refrigerator the precipitate obtained is filtered off and recrystallized from 300 ml ethanol-hexane, to yield the 8-(3-pyridyl)-8-azaspiro[4,5]decan-7,9-dione melting at 153°-154°.
후처리
- customThe starting material is prepared
- temperaturerefluxed for 48 hours
- customwhile collecting the water
- customformed
- temperatureAfter cooling in the refrigerator the precipitate
- customobtained
- filtrationis filtered off
- customrecrystallized from 300 ml ethanol-hexane
출처 및 근거
- ORD 기록
- ord-2f1c898da73c49e6806d3c06b02b64ab
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04255429
반응 노트
불러오는 중…