Hydrochloric Acid → N-2-methyl-2-(methylthio)propanoyl-L-cysteine
반응식
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10](Cl)=[O:11].Cl>C(=O)([O-])[O-].[K+].[K+]>[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10]([NH:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4])=[O:11]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.
후처리
- additionAfter the addition
- stirringthe mixture is stirred overnight at room temperature
- customthe obtained crystals are separated by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-1ca328e86dbf4115a5c3fbcde3584ea3
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04255446
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