Hydrochloric Acid → 5-(2-Fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride
반응식
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1참가 물질
4
실험 절차
5-(2-Fluoro-6-methyl-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep114, 691 mg, 2.76 mmol) was dissolved in 4M HCl in dioxane solution (7 ml). After refluxing the reaction mixture for 45 minutes, the solvent was removed under vacuum to give 667 mg of the title compound (93% yield)
후처리
- temperatureAfter refluxing the reaction mixture for 45 minutes
- customthe solvent was removed under vacuum
출처 및 근거
- ORD 기록
- ord-3fb63e5718eb421b975c24ab94c9dd0a
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07727988B2
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