Thionyl Chloride → 7-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride
반응식
S(Cl)([Cl:3])=O.[CH3:5][NH:6][S:7]([C:10]1[CH:11]=[C:12]([C:20]([OH:22])=O)[C:13]2[O:18][CH2:17][CH2:16][O:15][C:14]=2[CH:19]=1)(=[O:9])=[O:8]>C(Cl)(Cl)Cl>[CH3:5][NH:6][S:7]([C:10]1[CH:11]=[C:12]([C:20]([Cl:3])=[O:22])[C:13]2[O:18][CH2:17][CH2:16][O:15][C:14]=2[CH:19]=1)(=[O:9])=[O:8]참가 물질
4
실험 절차
176.5 g of thionyl chloride were introduced into a balloon flask provided with a condenser. Then, in portions, 135 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carboxylic acid were added under heating at 40°-45° C. The mixture was heated under reflux and then treated with 250 cm3 chloroform. The precipitate was dried off and washed with chloroform.
후처리
- customprovided with a condenser
- temperatureunder heating at 40°-45° C
- temperatureThe mixture was heated
- temperatureunder reflux
- customThe precipitate was dried off
- washwashed with chloroform
출처 및 근거
- ORD 기록
- ord-7c5079e88a35498fb213127bef9295c0
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04255580
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