Water → 1,2,3,5,6,8a-Hexahydroindolizine-7-methanol
반응식
[CH2:1]1[CH:9]2[N:4]([CH2:5][CH2:6][C:7]([C:10](OCC)=[O:11])=[CH:8]2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[CH2:1]1[CH:9]2[N:4]([CH2:5][CH2:6][C:7]([CH2:10][OH:11])=[CH:8]2)[CH2:3][CH2:2]1참가 물질
6
실험 절차
Ethyl 1,2,3,5,6,8a-hexahydroindolizine-7-carboxylate (D1, 0.89 g, 4.6 mmol) was stirred under Ar in dry THF (50 ml) as lithium aluminium hydride (0.35 g, 9.2 mmol) was added portionwise. After 30 min, the reaction was worked up by successive addition of water (0.35 ml), 10% NaOH (0.35 ml) and water (1.05 ml). The solid was filtered off, and the filtrate was evaporated to yield the title compound (0.67 g, 97%) as a brown oil.
후처리
- additionwas added portionwise
- filtrationThe solid was filtered off
- customthe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-84bee37117a24bd39308a70e372cb6f6
- 출처 데이터셋
- uspto-grants-2000_12
- 특허 번호
- US06156783
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