Hydrogen Bromide → 4-(3-Bromofuran-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

HRID 1274346노트

반응식

HRID 1274346 반응식
[C:1]([C:3]1[C:7]([CH:8]([OH:18])[C:9]#[C:10][CH:11](OCC)OCC)=[CH:6][N:5]([C:19]2[C:24]([Cl:25])=[CH:23][C:22]([C:26]([F:29])([F:28])[F:27])=[CH:21][C:20]=2[Cl:30])[N:4]=1)#[N:2].[BrH:31].O.CCOCC>O1CCOCC1>[Br:31][C:9]1[CH:10]=[CH:11][O:18][C:8]=1[C:7]1[C:3]([C:1]#[N:2])=[N:4][N:5]([C:19]2[C:24]([Cl:25])=[CH:23][C:22]([C:26]([F:27])([F:28])[F:29])=[CH:21][C:20]=2[Cl:30])[CH:6]=1

참가 물질

6

반응물 4

HCID 260Hydrogen BromideHCID 962WaterHCID 3283Diethyl EtherHCID 221208993-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(4,4-diethoxy-1-hydroxybut-2-ynyl)pyrazole

생성물 1

HCID 99116334-(3-Bromofuran-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a stirred solution of 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(4,4-diethoxy-1-hydroxybut-2-ynyl)pyrazole (0.04 g) in dioxane (1 ml) was added dropwise at room temperature hydrobromic acid (0.04 g). After 30 minutes the reaction mixture was poured into water (10 ml) and ether (10 ml). The organic layer was separated, dried (MgSO4) and evaporated. Recrystallisation from ether/hexane gave the title compound as a pale brown solid, m.p. 99-101° C.

후처리

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. customRecrystallisation from ether/hexane

출처 및 근거

ORD 기록
ord-dadf621e28264c99bf5815c02c3458c9
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06156782

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