Iodoethane → 1-Chloro-4-ethoxy-2-nitrobenzene

HRID 1274365

반응식

HRID 1274365 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](I)[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH3:13]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 691274-Chloro-3-nitrophenol

생성물 1

HCID 2407341-Chloro-4-ethoxy-2-nitrobenzene수율 97.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 4-chloro-3-nitrophenol (5.00 g, 29 mmol) in acetone (50 ml) were added ethyl iodide (4.95 g, 32 mmol) and potassium carbonate (4.37 g, 32 mmol), followed by stirring at room temperature for 20 hours. After filtration of the insoluble matter, the filtrate was subjected to evaporation under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography (eluent; chloroform) to give 4-ethoxy-1-chloro-2-nitrobenzene (5.71 g).

후처리

  1. filtrationAfter filtration of the insoluble matter
  2. customthe filtrate was subjected to evaporation under reduced pressure
  3. customto remove the solvent
  4. customthe residue was purified by silica gel column chromatography (eluent; chloroform)

출처 및 근거

ORD 기록
ord-46792c3674284c289776725f648199e7
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06156801

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