Hydrochloric Acid → 1-(4-Amino-5-fluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

HRID 1274730노트

반응식

HRID 1274730 반응식
Cl.[NH2:2][C:3]1[C:8]([F:9])=[CH:7][N:6]=[C:5]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([F:21])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([O:26]CC)=[O:25])=[CH:11]2)[CH:4]=1>C(O)(=O)C>[NH2:2][C:3]1[C:8]([F:9])=[CH:7][N:6]=[C:5]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([F:21])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22121193Ethyl 1-(4-amino-5-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

생성물 1

HCID 221211881-(4-Amino-5-fluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid수율 95.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To 400 mg of the mixed solution (1:1) of 4N hydrochloric acid and acetic acid was added 35 mg of ethyl 1-(4-amino-5-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux with stirring for 3 hours and allowed to cool. The precipitate was collected by filtration, and washed with distilled water, ethanol and diisopropylether successively to obtain 31 mg of the title compound as a pale yellow powder.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux
  3. temperatureto cool
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with distilled water, ethanol and diisopropylether successively

출처 및 근거

ORD 기록
ord-101ee500cd0e49e2b01a0591d39b9ec1
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06156903

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