Diisopropyl Ether → HCID 10563070, 화합물

HRID 1274961노트

반응식

HRID 1274961 반응식
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1.C(OC(C)C)(C)C>C(O)=O>[CH:1]([NH:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1)=[O:3]

참가 물질

5

반응물 3

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 11241673(Z)-2-(Acetoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

생성물 1

HCID 10563070HCID 10563070, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

To acetic anhydride (20.6 ml) was added formic acid (16.6 ml) at 15° C. The mixture was stirred at room temperature for 30 minutes. To the mixture was 2-(2-aminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (10 g) under ice-cooling, and the reaction mixture was stirred at room temperature for 20 hours. To the mixture was added isopropyl ether (37.2 ml) under ice-cooling, and the mixture was stirred at the same temperature for 1 hour. The resulting precipitate was collected by filtration to give 2-(2-formylaminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (9.39 g).

후처리

  1. temperaturecooling
  2. stirringthe reaction mixture was stirred at room temperature for 20 hours
  3. temperaturecooling
  4. stirringthe mixture was stirred at the same temperature for 1 hour
  5. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-eda6e46b1f484585af68f876719548ab
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159961

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