Hydrochloric Acid → (R)-4-chloro-1-(3,5-dimethylphenyl)-3-methylbutan-1-one

HRID 1275185노트

반응식

HRID 1275185 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([CH3:17])[CH:16]=1)[C:5]([C@H:7]1[CH:11]([CH3:12])[CH2:10]OC1=O)=[O:6].[ClH:18].C(=O)(O)[O-].[Na+]>>[Cl:18][CH2:10][C@H:11]([CH3:12])[CH2:7][C:5]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:16]=[C:15]([CH3:17])[CH:14]=1)=[O:6]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium Bicarbonate2회HCID 53860757(R)-3-(3,5-dimethylbenzoyl)-4-methyldihydrofuran-2-one

생성물 1

HCID 53672991(R)-4-chloro-1-(3,5-dimethylphenyl)-3-methylbutan-1-one

실험 절차

To a solution of (R)-3-(3,5-dimethylbenzoyl)-4-methyldihydrofuran-2-one (2.42 g in 15 mL dioxane) was added 15 mL conc. hydrochloric acid and the mixture heated to reflux on an oil bath. After one hour, the reaction was poured into cold, saturated aqueous sodium bicarbonate. Additional solid sodium bicarbonate was added until all acid was neutralized. This was then extracted with ethyl acetate, washed with brine. Concentration in vacuo provided the title compound (2.12 g).

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux on an oil bath
  3. extractionThis was then extracted with ethyl acetate
  4. washwashed with brine
  5. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-416ee6ec866d44078a574ba1abe4bd43
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159989

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