Methyl iodide → Acetylcholine Iodide

HRID 1275370

반응식

HRID 1275370 반응식
[CH3:1][N:2]([CH2:4][CH2:5][OH:6])[CH3:3].[3H][CH2:8][C:9](ON1C(=O)C2=CC=CC=C2C1=O)=[O:10].[CH3:23][I:24]>C(#N)C>[I-:24].[C:9]([O:6][CH2:5][CH2:4][N+:2]([CH3:23])([CH3:3])[CH3:1])(=[O:10])[CH3:8]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 79022-(Dimethylamino)ethanolHCID 10488521HCID 10488521, 화합물

생성물 1

HCID 75271Acetylcholine Iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

반응 조건

온도
75 °C

실험 절차

N,N-Dimethylaminoethanol (4 μL, 0.04 mmole) was dissolved in dry acetonitrile (0.25 mL) and was placed in a reaction vessel connected to the vacuum line. N-tritioacetoxyphthalimide (0.04 mmole, specific activity 13 Ci/mmole) in dry acetonitrile (0.8 mL) was then added through the side-arm of the reaction vessel. The mixture was heated at 75° C. for 2 hours under N2, then brought to room temperature and methyl iodide (20 μL) was injected. The mixture was stirred for 1 hour. The solvent and excess of methyl iodide was evaporated under vacuum. Deuteriated water (0.5 mL) was added and removed. D2O (1 mL) was then added to the residue and filtered and the product was analyzed by 1H and 3H NMR spectroscopy.

후처리

  1. customwas placed in a reaction vessel
  2. custombrought to room temperature
  3. customThe solvent and excess of methyl iodide was evaporated under vacuum
  4. additionDeuteriated water (0.5 mL) was added
  5. customremoved
  6. additionD2O (1 mL) was then added to the residue
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-9a70f0f9c217492ba5b74e4a4ac0990c
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06160128

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