N-bromobutanimide → 2-Bromomethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-one

HRID 1275902노트

반응식

HRID 1275902 반응식
[CH3:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6](=[O:16])[C:7]3[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.[Br:19]N1C(=O)CCC1=O>C(OCC)(=O)C>[Br:19][CH2:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6](=[O:16])[C:7]3[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 221172592,8-dimethyl-5H-dibenzo[a,d][7]annulen-5-one

생성물 1

HCID 221172722-Bromomethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-one

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The product of step (i) (2.0 g) and N-bromosuccinimide (1.52 g) in ethyl acetate (80ml) was irradiated with a 500 W halogen lamp for 4 hours. The reaction mixture was washed with brine, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with toluene. Used directly in the next step.

후처리

  1. washThe reaction mixture was washed with brine
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customPurification
  5. washeluting with toluene

출처 및 근거

ORD 기록
ord-4d603e7f5bba488d825ad0603cbf16b3
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06162808

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