Dichloromethane → H-Phe-Met-OMe.HCl

HRID 127604노트

반응식

HRID 127604 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)[Cl:30]>Cl>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:30]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 8022451tert-Butoxycarbonyl-phenylalanyl-methionine methyl ester

생성물 1

HCID 67685067H-Phe-Met-OMe.HCl

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

11.83 g of Boc-Phe-Met-OMe (see Biochemistry, 8, 4183 (1969), incorporated herein) is dissolved in 100 ml methylene chloride after which HCl is passed into the solution for about 40 minutes. After evaporation of the solution to dryness, 75 ml ethyl acetate is added, resulting in a precipitate. The solid substance is separated by filtration, washed with petroleum ether, and dried. Melting point 123°-124° C. Rf in To:EtOH (8:2)=0.43 on SiO2.

후처리

  1. customAfter evaporation of the solution to dryness, 75 ml ethyl acetate
  2. additionis added
  3. customresulting in a precipitate
  4. customThe solid substance is separated by filtration
  5. washwashed with petroleum ether
  6. customdried

출처 및 근거

ORD 기록
ord-6c4d992ebbd846aa81b24e6a96ca344f
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256736

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