Lithium Hydroxide → (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([O:18]CC3C=CC=CC=3)=[O:17])=[N:7][C:6]=2[CH:26]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([OH:18])=[O:17])=[N:7][C:6]=2[CH:26]=1

참가 물질

반응물 2

HCID 3939Lithium Hydroxide

HCID 53932308benzyl(2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate

생성물 1

HCID 53730159(2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

실험 절차

The title compound was prepared by a similar method to Preparation 3 from benzyl (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 28] and 1N aqueous lithium hydroxide solution to afford (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as an oil.

출처 및 근거

ORD 기록: ord-8709320d1e2a41ca8590d519688aee2c
출처 데이터셋: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06166011

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