Hydrazine hydrate (1:1) → 5-Bromo-1-naphthohydrazide

HRID 1276286

반응식

HRID 1276286 반응식
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([NH:17][NH2:18])=[O:14]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 4557673Methyl 5-bromo-1-naphthoate

생성물 1

HCID 221158865-Bromo-1-naphthohydrazide수율 65.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 5-bromo-1-naphthoate (D1) (5.32 g, 20 mmol) and hydrazine hydrate (5.7 ml, 100 mmol) were stirred at reflux in methanol (50 ml) for 48 h. After cooling, the solid was filtered off, washed with cold methanol, and dried in vacuo at 60° C., yielding the title compound (3.48 g, 65%) as a grey-brown crystalline powder.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. washwashed with cold methanol
  4. customdried in vacuo at 60° C.

출처 및 근거

ORD 기록
ord-df9142386daf43d2804491a3bbe60fda
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166034

연결된 노트

불러오는 중…