Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-ol

HRID 1276532노트

반응식

HRID 1276532 반응식
[CH3:1][Mg]Br.[CH3:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)=[O:6].O.Cl>C(OCC)C>[Br:13][C:9]1[CH:8]=[C:7]([C:5]([OH:6])([CH3:1])[CH3:4])[CH:12]=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 165023'-BromoacetophenoneHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 150723832-(3-Bromophenyl)propan-2-ol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a stirred solution of methylmagnesium bromide (60 mL of a 3.0 M solution in diethyl ether) at 0° C. was added dropwise a solution of 3-bromoacetophenone (29.8 grams) in 75 mL of diethyl ether. Once the addition was complete, the mixture was stirred for 0.5 hours and poured into water. The aqueous phase was acidified with 1M hydrochloric acid and extracted with three portions of diethyl ether. The combined ether layers were washed with saturated sodium bicarbonate, concentrated to afford 30.4 grams of the title compound. 1H NMR δ7.72 (br s, 1), 7.49 (d, 1, J=7.8), 7.37 (d, 1, J=7.9), 7.25 (dd, 1, J=7.8, 7.9), 4.19 (s, 1), 1.50 (br s, 6).

후처리

  1. additionOnce the addition
  2. extractionextracted with three portions of diethyl ether
  3. washThe combined ether layers were washed with saturated sodium bicarbonate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0df5965ff49c4ffdb52213cbd0310d10
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166064

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