Hydrochloric Acid → 2,4-dioxo-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile hydrochloride

HRID 12766노트

반응식

HRID 12766 반응식
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]#[N:10])=[CH:4][N:3]1[CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[CH2:20][C@H:19]2[C@:17]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)([CH2:18]2)[CH2:16]1.[ClH:31]>O1CCOCC1>[ClH:31].[O:1]=[C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]#[N:10])=[CH:4][N:3]1[CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[CH2:20][C@H:19]2[C@:17]([C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=3)([CH2:18]2)[CH2:16]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 247591182,4-dioxo-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile

생성물 1

HCID 686937242,4-dioxo-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2,4-dioxo-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile was treated with a solution of 4N HCl in dioxane (200 μl) to give the title compound as a pale yellow solid. (76 mg).

출처 및 근거

ORD 기록
ord-6cefeec708104acc93a0cdf1c7e079f2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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