Benzyl Bromide → 1-(Phenylmethyl)-1H-1,2,4-triazole

HRID 127660

반응식

HRID 127660 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:9]1[CH:13]=[N:12][CH:11]=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 92571H-1,2,4-TriazoleHCID 11430Potassium Carbonate

생성물 1

HCID 224581-(Phenylmethyl)-1H-1,2,4-triazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 34.2 parts by weight of benzyl bromide, 13.8 parts by weight of 1,2,4-triazole and 41.4 parts by weight of potassium carbonate in 150 parts by weight of acetonitrile is refluxed for 10 hours while stirring. The mixture is filtered and the filtrate is evaporated to dryness and recrystallized from a mixture of toluene and cyclohexane. There is obtained 21 parts by weight of 1-benzyl-1,2,4-triazole; m.p.: 58° C.

후처리

  1. temperatureis refluxed for 10 hours
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customrecrystallized from a mixture of toluene and cyclohexane

출처 및 근거

ORD 기록
ord-26e929fcdfca4b17826444a9104df6a9
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256754

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