Triethylamine → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-

HRID 127716

반응식

HRID 127716 반응식
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C([N:12](CC)CC)C.S(O)(O)(=O)=O.NO>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:12]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 159255Hydroxylamine, sulfate (1:1)

생성물 1

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-수율 81.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of pivaloylacetonitrile (12.52 g) and triethylamine (11.27 g) in water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g). pH 8.22. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (11.45 g; yield, 81.7%).

후처리

  1. additionThe reaction mixture is treated as in Example 2

출처 및 근거

ORD 기록
ord-d73c023895844ceaa0b5ec960b928bde
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256899

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