Hydrochloric Acid → HCID 13020006, 화합물

HRID 1277818노트

반응식

HRID 1277818 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([N:17]([CH2:19][CH:20](OC)OC)[CH3:18])=[O:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>O>[CH3:18][N:17]1[CH:19]=[CH:20][N:14]([C:11]2[CH:10]=[CH:9][C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:13][CH:12]=2)[C:15]1=[O:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13020004HCID 13020004, 화합물

생성물 1

HCID 13020006HCID 13020006, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-(4-Phenoxyphenyl)-N'-(2,2-dimethoxyethyl)-N'-methylurea (5.0 grams, 0.015 mole), water (30 ml) and concentrated hydrochloric acid (3 ml) were charged into a glass reaction vessel fitted with a mechanical stirrer thermometer and condenser. The reaction mixture was refluxed for a period of about 15 minutes, cooled and extracted with ethyl acetate. The ethyl acetate solution was washed with dilute aqueous sodium bicarbonate and with portions of water and dried. The ethyl acetate was removed by mild warming under reduced pressure to yield a residue. This was recrystallized from ethyl acetate to yield the desired product 1-methyl-3-(4-phenoxyphenyl)-4-imidazolin-2-one as a solid having a melting point of 112° C.

후처리

  1. customfitted with a mechanical stirrer thermometer and condenser
  2. temperatureThe reaction mixture was refluxed for a period of about 15 minutes
  3. temperaturecooled
  4. extractionextracted with ethyl acetate
  5. washThe ethyl acetate solution was washed with dilute aqueous sodium bicarbonate and with portions of water
  6. customdried
  7. customThe ethyl acetate was removed
  8. temperatureby mild warming under reduced pressure
  9. customto yield a residue
  10. customThis was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-330ba492c03448bc856b722bf356a075
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279637

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